Structure of PDB 7x6s Chain A

Receptor sequence
>7x6sA (length=1453) Species: 11624 (Lymphocytic choriomeningitis virus (strain Armstrong)) [Search protein sequence]
MDEIISELRELCLNYIEQDERLSRQKLNFLGQREPRMVLIEGLKLLSRCI
EIDSADKSGCTHNHDDKSVETILVESGIVCPGLPLIIPDGYKLIDNSLIL
LECFVRSTPASFEKKFIEDTNKLACIREDLAVAGVTLVPIVDGRCDYDNS
FMPEWANFKFRDLLFKLLEYSNQNEKVFEESEYFRLCESLMDSMKILKDA
RSTHNDEIMRMCHEGINPNMSCDDVVFGINSLFSRFRRDLESGKLKRNFQ
KVNPEGLIKEFSELYENLADSDDILTLSREAVESCPLMRFITAETHGTEY
ERLLSMLNKVKSLKLLNTRRRQLLNLDVLCLSSLIKQSCYSSVNDRLVSF
HSTKEEFIRLLRNRKKSKVRASISEFIAKIQKCLLVVGLSFEHYGLSEHL
EQECHIPFTEFENFMKIGAHPIMYYNFQPSTEQLKNIQSLRRLSSVCLAL
TNSMKTSSVCKEVFCQVIKLDSEEYHLLYQKTGESSRCYSIQGPDGHLIS
FYADPKRFFLPIFSDEVLYNMIDIMISWIRSCPDLKDCLTDIEVALRTLL
LLMLTNPTKRNQKQVQSVRYLVMAIVSDFSSTSLMDKLREDLITPAEKVV
YKLLRFLIKTIFGTGEKVLLSAKFKFMLNVSYLCHLITKETPDRLTDQIK
CFEKFFEPKSQFGFFVNPKEAITPEEECVFYEQMKRFTSKEIDCQHTTPG
VNLEAFSLMVSSFNNGTLIFLLVSAVSQITESFVRKYEYKVSKLVSRLVI
GSKGEETGRSEDCFDGEEETSFFKSLEEKVNTTIARYRRGRRAHLQLILT
GKMAHLRKVILSEMSAALKNLCFYSEESPTSYTSVGPDSGRLKFALSYKE
QVGGNRELYIGDLRTKMFTRLIEDYFESFSSFFSGSCLNNDKEFENAILS
MTINVREGFLNYSMDHSKWGPMMCPFLFLMFLQNLKLGDDQYVRSGKDHV
STLLTWHMHKLVEVPFPVVNAMMKSYVKSKLKETTVTERIFRQYFEMGIV
PSHISSLIDMGQGILHNASDFYGLLSERFINYCIGVIFGERPEAYTSSDD
QITLFDRRLSDLVVSDPEEVLVLLEFQSHLSGLLNKFISPKSVAGRFAAE
FKSRFYVWGEEVPLLTKFVSAALHNVKCKEPHQLCETIDTIADQAIANGV
PVSLVNSIQRRTLDLLKYANFPLDPFLLNTNTDVKDWLDGSRGYRIQRLI
EELCPNETKVVRKLVRKLHHKLKNGEFNEEFFLDLFNRDKKEAILQLGDL
LGLEEDLNQLADVNWLNLNEMFPLRMIPSLIKTLQNKLCISSGFIGLCKT
LGSRCVRNKNRENLYIKKLLEDLTTDDHVTRVCNRDGITLYICDKQSHPE
AHRDHICLLRPLLWDYICISLSNSFELGVWVLAEPKVNLNQVIQSVRRLY
PKIFEDQLLPIKFLDLCVLIDINSESLSLISHVVKWKRDEHYTVLFSDLA
NSH
3D structure
PDB7x6s Structure basis for allosteric regulation of lymphocytic choriomeningitis virus polymerase function by Z matrix protein.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D1182 D1322 E1372 D915 D1050 E1100
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7x6s, PDBe:7x6s, PDBj:7x6s
PDBsum7x6s
PubMed37038286
UniProtP14240|L_LYCVA RNA-directed RNA polymerase L (Gene Name=L)

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