Structure of PDB 7x5n Chain A

Receptor sequence
>7x5nA (length=409) Species: 1352 (Enterococcus faecium) [Search protein sequence]
DYKTFDPDLWAAIAKEEERQEHNLELIASENFVSEAVMAAQGSILTNKYA
EGYPGHRYYGGCEFVDIVENLAIDRAKELFGAKFANVQPHSGSQANTAAY
LALVEPGDTILGMDLSAGGHLTHGSPVNFSGKTYHFVAYGVDPTTEVIDY
NVVRILARKHQPKLIVAGASAYGRTIDFAKFREIADEVGAKLMVDMAHIA
GLVAAGLHPNPVPYADITTTTTHKTLRGPRGGMILTNDEALAKKINSAVF
PGIQGGPLEHVIAGKAVAFKEALDPAFKEYSEQIIANAKAMVKVFNQAIG
TRVISGATDNHLMLIDVRELGINGKEAESILDSVNITVNKNSIPFETLSP
FKTSGIRIGTPAITTRGFKEEDAVKVAELVVKALQAKDDNAQLDEVKTGV
RELTEKFPL
3D structure
PDB7x5n Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.2.1: glycine hydroxymethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5M5 A L117 G121 H122 L123 K342 N343 S344 P352 F353 R359 L115 G119 H120 L121 K340 N341 S342 P350 F351 R357
BS02 PLS A S31 S93 G94 S95 H122 S172 D197 A199 H200 K226 R359 S29 S91 G92 S93 H120 S170 D195 A197 H198 K224 R357
BS03 5M5 A E53 Y60 Y61 E51 Y58 Y59
BS04 PLS A Y51 E53 Y61 Y49 E51 Y59
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004372 glycine hydroxymethyltransferase activity
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
GO:0030170 pyridoxal phosphate binding
GO:0050897 cobalt ion binding
GO:0070905 serine binding
Biological Process
GO:0006545 glycine biosynthetic process
GO:0006565 L-serine catabolic process
GO:0006730 one-carbon metabolic process
GO:0008652 amino acid biosynthetic process
GO:0019264 glycine biosynthetic process from serine
GO:0032259 methylation
GO:0035999 tetrahydrofolate interconversion
GO:0046653 tetrahydrofolate metabolic process
GO:0046655 folic acid metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7x5n, PDBe:7x5n, PDBj:7x5n
PDBsum7x5n
PubMed35739195
UniProtI3U4H4

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