Structure of PDB 7x4q Chain A

Receptor sequence
>7x4qA (length=291) Species: 446 (Legionella pneumophila) [Search protein sequence]
SIDWEQTFRKWSKPSSETESTKAENAERMIKAAINSSQILSTKDISVFPQ
GSYRNNTNVREDSDVDICVCLNTLVLSDYSLVPGMNASYTYKQFKSDLET
ALKNKFGTLGVSRGDKAFDVHANSYRVDADVVPAIQGRLYYDKNHNAFIR
GTCIKPDSGGTIYNWPEQNYSNGVNKNKSTGNRFKLIVRAIKRLRNHLAE
KGYNTAKPIPSYLMECLVYIVPDQYFTGDSYKTNVENCINYLYNQIDSSD
WTEINEIKYLFGSHQMWNKTQVKEFLLTAWSYIQKNLEHHH
3D structure
PDB7x4q Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UTP A G52 S53 D67 K201 S220 Y221 W276 G51 S52 D66 K192 S211 Y212 W267
BS02 UTP A D67 D124 K125 A126 D139 I163 N173 D66 D115 K116 A117 D130 I154 N164
BS03 MG A D67 D139 D66 D130
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0009117 nucleotide metabolic process
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7x4q, PDBe:7x4q, PDBj:7x4q
PDBsum7x4q
PubMed37604815
UniProtP0DSP3|CDNE2_LEGPN Cyclic dipyrimidine nucleotide synthase CdnE (Gene Name=cdnE02)

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