Structure of PDB 7x3p Chain A

Receptor sequence
>7x3pA (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
PSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDL
ATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRV
VVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALS
GKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEV
DRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRF
RFHFQGPCGTTLPEALA
3D structure
PDB7x3p Crystal structure of human SIRT5 in complex with diazirine inhibitor 9
ChainA
Resolution1.56 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8VG A Q83 Y102 R105 H158 V221 F223 G224 E225 N226 V254 Y255 Q48 Y67 R70 H123 V186 F188 G189 E190 N191 V219 Y220
BS02 ZN A C166 C169 C207 C212 C131 C134 C172 C177
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:7x3p, PDBe:7x3p, PDBj:7x3p
PDBsum7x3p
PubMed
UniProtQ9NXA8|SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=SIRT5)

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