Structure of PDB 7x24 Chain A

Receptor sequence
>7x24A (length=986) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GMDLDDHRLSNTELEQKYGTNIIQGLSSVRATELLARDGPNTLTPPKQTP
EIIKFLKQMVGGFSILLWIGAALCWIAFVIQYVNNSASLDNVYLGAILVL
VVILTGIFAYYQEAKSTNIMASFSKMIPQQALVIRDAEKKVISAEQLVVG
DVVEIKGGDQIPADIRLVFSQGCKVDNSSLTGESEPQARSTEFTHENPLE
TKNIGFYSTTCLEGTATGIVINTGDRTIIGRIASLASGVGSEKTPIAIEI
EHFVHIVAGVAVSIDIIFFITAVCMKYYVLDAIIFLISIIVANVPEGLLA
TVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTV
AHLWFDNQIFVADTSENQTKQAFDQSSGTWASLSKIITLCNRAEFRPGQE
SVPIMKRTVVGDASETALLKFSEVILGDVMGIRKRNHKVAEIPFNSTNKF
QLSIHETEDPNNKRFLVVMKGAPERILEKCSTIMINGQEQPLDKSSADSF
HTAYMELGGLGERVLGFCHLYLPAEQFPQSYIFDVDSVNFPTSNFCFVGL
LSMIDPPRSTVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANN
ETVEDIAKRRNIAVEQVNKREAKAAVVTGMELKDMTPEQLDELLTNYQEI
VFARTSPQQKLIIVEGCQRQDAIVAVTGDGVNDSPALKKADIGIAMGIAG
SDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYTLTSNIPELC
PFLIYIVAGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRH
KKKDRLVNTQLAIYSYLHIGLMQALGGFLVYFTVYAQQGFWPTSLINLRV
AWETDDINDLEDSYGQEWTRYQRKYLEWTGSTAFFVAIMIQQWADLIICK
TRRNSIFQQGLFRNKVIWVGIASQVIVALILSYGLGSVPALSFTMLRVQY
WFVAVPHAILIWVYDEMRKLFIRLYPGSWWDKNMYY
3D structure
PDB7x24 Structure and function of H + /K + pump mutants reveal Na + /K + pump mechanisms.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.2.2.13: Na(+)/K(+)-exchanging ATPase.
7.2.2.19: H(+)/K(+)-exchanging ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR A G309 V310 G259 V260
BS02 CLR A W943 L979 Y983 W1001 F1002 W893 L929 Y933 W951 F952
BS03 ALF A G232 D388 T390 K710 N732 D733 G182 D338 T340 K660 N682 D683
BS04 MG A D388 T390 D729 D338 T340 D679
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005391 P-type sodium:potassium-exchanging transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008556 P-type potassium transmembrane transporter activity
GO:0008900 P-type potassium:proton transporter activity
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
Biological Process
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006883 intracellular sodium ion homeostasis
GO:0006885 regulation of pH
GO:0010038 response to metal ion
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0014070 response to organic cyclic compound
GO:0030007 intracellular potassium ion homeostasis
GO:0036376 sodium ion export across plasma membrane
GO:0055075 potassium ion homeostasis
GO:1902600 proton transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7x24, PDBe:7x24, PDBj:7x24
PDBsum7x24
PubMed36085139
UniProtP54708|AT12A_RAT Potassium-transporting ATPase alpha chain 2 (Gene Name=Atp12a)

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