Structure of PDB 7x12 Chain A

Receptor sequence
>7x12A (length=564) Species: 9606 (Homo sapiens) [Search protein sequence]
PRRRHTHQRGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQV
LRVVKNFEHLNSDFDRYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPT
VGLACQQYSLVFRKPRGLFITIHDRGHIASVLNAWPEDVIKAIVVTDGER
ILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPVILDVGTENEELLKD
PLYIGLRQRRVRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRL
LNKYRNQYCTFNDDIQGTASVAVAGLLAALRITKNKLSDQTILFQGAGEA
ALGIAHLIVMALEKEGLPKEKAIKKIWLVDSKGLIVKGRASLTQEKEKFA
HEHEEMKNLEAIVQEIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFA
LSNPTSKAECSAEQCYKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNS
YVFPGVALGVVACGLRQITDNIFLTTAEVIAQQVSDKHLEEGRLYPPLNT
IRDVSLKIAEKIVKDAYQEKTATVYPEPQNKEAFVRSQMYSTDYDQILPD
CYSWPEEVQKIQTK
3D structure
PDB7x12 Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP + -Dependent Malic Enzyme 1.
ChainA
Resolution2.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.40: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A E255 D256 D279 E240 D241 D264
BS02 NDP A R165 T283 Q310 A312 G313 E314 A315 D345 S346 K347 K361 V389 A390 I392 L416 S417 N418 G462 N464 R150 T268 Q295 A297 G298 E299 A300 D330 S331 K332 K346 V374 A375 I377 L401 S402 N403 G447 N449
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004470 malic enzyme activity
GO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity
GO:0005515 protein binding
GO:0008948 oxaloacetate decarboxylase activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0030145 manganese ion binding
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0046872 metal ion binding
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006090 pyruvate metabolic process
GO:0006108 malate metabolic process
GO:0006734 NADH metabolic process
GO:0006739 NADP metabolic process
GO:0009165 nucleotide biosynthetic process
GO:0009725 response to hormone
GO:0009743 response to carbohydrate
GO:0051289 protein homotetramerization
GO:1902031 regulation of NADP metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7x12, PDBe:7x12, PDBj:7x12
PDBsum7x12
PubMed35819845
UniProtP48163|MAOX_HUMAN NADP-dependent malic enzyme (Gene Name=ME1)

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