Structure of PDB 7wzv Chain A

Receptor sequence

>7wzvA (length=300) Species: 68270 (Streptomyces spectabilis) [Search protein sequence]

VRLADGKVRNPEGIEVNASLQCNMRCQSCAHLSPLYRRENADPAEIHDTL
SVLARSYHASYAKIMGGEPLLHPDVVGLIEAVRATGISDTVLVATNGTLL
HRATERFWQAVDSLEISVYPSRMIAPEEIERYRVLAREHGVSLLVNYYGH
FRAVYSESGTDAPDLVRDVFDTCKLAHFWNSHTVYDGWLYRCPQSVFMPR
QLRDGGWDPRVDGLRIEDDPAFLERLHRFLTADDPLRACRNCLGSVGKLH
PHQELPRAGWQVTEQLAALVDYPFLKVCKDDITADDGCVERSLSAPVGGA

3D structure

PDB

7wzv Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase.

Chain

Resolution

1.89931 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	SF4	A	C24 M26 C28 C31 P36 G69 N98 Y121 F153	C22 M24 C26 C29 P34 G67 N96 Y119 F151
BS02	SF4	A	C175 C194 Q196 L238 A240 C241 C244 G246	C173 C192 Q194 L236 A238 C239 C242 G244
BS03	SAM	A	S30 A32 H33 M67 G69 S119 Y121 Y150 F153 R154	S28 A30 H31 M65 G67 S117 Y119 Y148 F151 R152
BS04	7P8	A	E17 H33 K65 M67 L177 W181 P195	E15 H31 K63 M65 L175 W179 P193

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

View graph for
Molecular Function

External links

PDB	RCSB:7wzv, PDBe:7wzv, PDBj:7wzv
PDBsum	7wzv
PubMed	35622017
UniProt	A8WEZ7

[Back to BioLiP]