Structure of PDB 7wyv Chain A

Receptor sequence
>7wyvA (length=993) Species: 7797 (Squalus acanthias) [Search protein sequence]
DLDELKKEVSMDDHKLSLDELHNKYGTDLTRGLTNARAKEILARDGPNSL
TPPPTTPEWIKFCRQLFGGFSILLWIGAILCFLAYGIQAATEDEPANDNL
YLGVVLSTVVIVTGCFSYYQEAKSSRIMDSFKNMVPQQALVIRDGEKSTI
NAEFVVAGDLVEVKGGDRIPADLRIISAHGCKVDNSSLTGESEPQTRSPE
FSSENPLETRNIAFFSTNCVEGTARGVVVYTGDRTVMGRIATLASGLEVG
RTPIAIEIEHFIHIITGVAVFLGVSFFILSLILGYSWLEAVIFLIGIIVA
NVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGT
LTQNRMTVAHMWFDNQIHEADTTENQSGAAFDKTSATWSALSRIAALCNR
AVFQAGQDNVPILKRSVAGDASESALLKCIELCCGSVQGMRDRNPKIVEI
PFNSTNKYQLSIHENEKSSESRYLLVMKGAPERILDRCSTILLNGAEEPL
KEDMKEAFQNAYLELGGLGERVLGFCHFALPEDKYNEGYPFDADEPNFPT
TDLCFVGLMAMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKG
VGIISEGNETIEDIAARLNIPIGQVNPRDAKACVVHGSDLKDLSTEVLDD
ILHYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADI
GVAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTL
TSNIPEITPFLVFIIGNVPLPLGTVTILCIDLGTDMVPAISLAYEQAESD
IMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLP
MDLIGKRVRWDDRWISDVEDSFGQQWTYEQRKIVEFTCHTSFFISIVVVQ
WADLIICKTRRNSIFQQGMKNKILIFGLFEETALAAFLSYCPGTDVALRM
YPLKPSWWFCAFPYSLIIFLYDEMRRFIIRRSPGGWVEQETYY
3D structure
PDB7wyv Cryoelectron microscopy of Na + ,K + -ATPase in the two E2P states with and without cardiotonic steroids.
ChainA
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A X376 T378 D717 X346 T348 D687
BS02 MG A E786 D811 E756 D781
BS03 ATP A R240 E453 F482 K487 K508 L553 R210 E423 F452 K457 K478 L523
BS04 CLR A F989 F992 F959 F962
BS05 CLR A F867 E875 S986 F837 E845 S956
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005391 P-type sodium:potassium-exchanging transporter activity
GO:0005524 ATP binding
GO:0008556 P-type potassium transmembrane transporter activity
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
Biological Process
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006883 intracellular sodium ion homeostasis
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0030007 intracellular potassium ion homeostasis
GO:0036376 sodium ion export across plasma membrane
GO:1902600 proton transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wyv, PDBe:7wyv, PDBj:7wyv
PDBsum7wyv
PubMed35380894
UniProtQ4H132

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