Structure of PDB 7wwt Chain A

Receptor sequence
>7wwtA (length=153) Species: 9615 (Canis lupus familiaris) [Search protein sequence]
MEMKAVCVLKGQGPVEGTIHFVQKGSGPVVVSGTITGLTEGEHGFHVHQF
GDNTQGCTSAGPHFNPLSKKHGGPKDQERHVGDLGNVTAGKDGVAIVSIE
DSLIALSGDYSIIGRTMVVHEKRDDLGKGDNEESTQTGNAGSRLACGVIG
IAQ
3D structure
PDB7wwt Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy-linked E40K mutation.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.15.1.1: superoxide dismutase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H63 H71 H80 D83 H63 H71 H80 D83
BS02 CU A H46 H48 H63 H120 H46 H48 H63 H120
Gene Ontology
Molecular Function
GO:0004784 superoxide dismutase activity
GO:0005507 copper ion binding
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006801 superoxide metabolic process
GO:0019430 removal of superoxide radicals
GO:0072593 reactive oxygen species metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:7wwt, PDBe:7wwt, PDBj:7wwt
PDBsum7wwt
PubMed37156398
UniProtQ8WNN6|SODC_CANLF Superoxide dismutase [Cu-Zn] (Gene Name=SOD1)

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