Structure of PDB 7wwb Chain A

Receptor sequence
>7wwbA (length=333) Species: 9606 (Homo sapiens) [Search protein sequence]
PLEDRSCTDIPWLLLFILFCIGMGFICGFSIATVLSMILMVIIRYISRVL
VWILTILFLIMLVMRKRVALTIALFHVAGKVFIHLPLLVFQPFWTFFALV
LFWVYWIMTLLFLMWWYHVVGLIWISEFILACQQMTVAGAVVTYYFTRDK
RNLPFTPILASVNRLIRYHLGTVAKGSFIITLVKIPRMILMYIHSQLCVL
KSCICCLWCLEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENALRV
ATINTVGDFMLFLGKVLIVCSTGLAGIMLLPLIIVCLFAFLVAHCFLSIY
EMVVDVLFLCFAIDTKYNDGSPGREFYMDKVLM
3D structure
PDB7wwb Rational exploration of fold atlas for human solute carrier proteins.
ChainA
Resolution3.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CHT A N533 E591 N254 E301
BS02 CLR A I399 I436 I129 I166
Gene Ontology
Molecular Function
GO:0015220 choline transmembrane transporter activity
GO:0015297 antiporter activity
GO:0022857 transmembrane transporter activity
GO:0034228 ethanolamine transmembrane transporter activity
Biological Process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0015871 choline transport
GO:0034229 ethanolamine transport
GO:0042426 choline catabolic process
GO:0055085 transmembrane transport
GO:0150104 transport across blood-brain barrier
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wwb, PDBe:7wwb, PDBj:7wwb
PDBsum7wwb
PubMed35700727
UniProtQ8WWI5|CTL1_HUMAN Choline transporter-like protein 1 (Gene Name=SLC44A1)

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