Structure of PDB 7wv5 Chain A

Receptor sequence
>7wv5A (length=659) Species: 9606 (Homo sapiens) [Search protein sequence]
TVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLT
SLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTEL
HLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLL
SNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFL
NNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTM
LDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLN
LKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGL
INLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFS
WLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFAL
VPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEG
LEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIP
VEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKK
VFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCN
TPPHYHGFP
3D structure
PDB7wv5 TLR3 forms a highly organized cluster when bound to a poly(I:C) RNA ligand.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A H39 K41 H60 Q62 F84 H108 E110 A519 K619 H11 K13 H32 Q34 F56 H80 E82 A491 K591
BS02 rna A R64 R65 T86 S88 N515 N517 H539 N541 S571 R36 R37 T58 S60 N487 N489 H511 N513 S543
External links
PDB RCSB:7wv5, PDBe:7wv5, PDBj:7wv5
PDBsum7wv5
PubMed36371424
UniProtO15455|TLR3_HUMAN Toll-like receptor 3 (Gene Name=TLR3)

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