Structure of PDB 7wta Chain A

Receptor sequence
>7wtaA (length=684) Species: 9606 (Homo sapiens) [Search protein sequence]
NRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPPPAGFRDI
LLREGPEGFARAVRNHPGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYV
AHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLR
GANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAG
SAGGVVEAAISYTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMA
GLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVV
DVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERVFDYSEYWEGARGL
YAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAY
VEANQMLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSV
VEFLQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGASLPPLDLQALEKEL
VDRHGEEVTPEDVLSAAMYPDVFAHFKDFTATFGPLDSLNTRLFLQGPKI
AEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSILVKDTQA
MKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMK
METVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE
3D structure
PDB7wta Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
ChainA
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.4.1.1: pyruvate carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BTI A R617 Y651 Q870 T908 K912 R123 Y157 Q376 T414 K418
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004736 pyruvate carboxylase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0009374 biotin binding
GO:0016874 ligase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006090 pyruvate metabolic process
GO:0006094 gluconeogenesis
GO:0006629 lipid metabolic process
GO:0006734 NADH metabolic process
GO:0006739 NADP metabolic process
GO:0010629 negative regulation of gene expression
GO:0019074 viral RNA genome packaging
GO:0019076 viral release from host cell
GO:0044794 positive regulation by host of viral process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wta, PDBe:7wta, PDBj:7wta
PDBsum7wta
PubMed36283412
UniProtP11498|PYC_HUMAN Pyruvate carboxylase, mitochondrial (Gene Name=PC)

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