Structure of PDB 7wq0 Chain A

Receptor sequence
>7wq0A (length=518) Species: 93062 (Staphylococcus aureus subsp. aureus COL) [Search protein sequence]
KETFYITTPIYYPSGNLHIGHAYSTVAGDVIARYKRMQGYDVRYLTGTDE
HGQKIQEKAQKAGKTEIEYLDEMIAGIKQLWAKLEISNDDFIRTTEERHK
HVVEQVFERLLKQGDIYLGEYEGWYSVPDETYYTESQLVDPQYENGKIIG
GKSPDSGHEVELVKEESYFFNISKYTDRLLEFYDQNPDFIQPPSRKNEMI
NNFIKPGLADLAVSRTSFNWGVHVPSNPKHVVYVWIDALVNYISALGYLS
DDESLFNKYWPADIHLMAKEIVRFHSIIWPILLMALDLPLPKKVFAHGWI
LMKDGKMSKSKGNVVDPNILIDRYGLDATRYYLMRELPFGSDGVFTPEAF
VERTNFDLANDLGNLVNRTISMVNKYFDGELPAYQGPLHELDEEMEAMAL
ETVKSYTESMESLQFSVALSTVWKFISRTNKYIDETTPWVLAKDDSQKDM
LGNVMAHLVENIRYAAVLLRPFLTHAPKEIFEQLNINNPQFMEFSSLEQY
GVLNESIMVTGQPKPIFP
3D structure
PDB7wq0 Fragment screening and structural analyses highlight the ATP-assisted ligand binding for inhibitor discovery against type 1 methionyl-tRNA synthetase.
ChainA
Resolution2.09 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.10: methionine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A Y13 Y14 H20 G22 H23 S26 A270 E272 I273 H299 W301 I302 K308 M309 K311 S312 Y11 Y12 H18 G20 H21 S24 A268 E270 I271 H297 W299 I300 K306 M307 K309 S310
BS02 TPA A P11 I12 W237 A240 N243 Y244 P9 I10 W235 A238 N241 Y242
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004825 methionine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006431 methionyl-tRNA aminoacylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7wq0, PDBe:7wq0, PDBj:7wq0
PDBsum7wq0
PubMed35474479
UniProtQ5HII6|SYM_STAAC Methionine--tRNA ligase (Gene Name=metG)

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