Structure of PDB 7wpt Chain A

Receptor sequence
>7wptA (length=483) Species: 93062 (Staphylococcus aureus subsp. aureus COL) [Search protein sequence]
SAKETFYITTPIYYPSGNLHIGHAYSTVAGDVIARYKRMQGYDVRYLTGT
DEHGQKIQEKAQKAGKTEIEYLDEMIAGIKQLWAKLEISNDDFIRTTEER
HKHVVEQVFERLLKQGDIYLGEYEGWELVKEESYFFNISKYTDRLLEFYD
QNPDFIQPPSRKNEMINNFIPGLADLAVSRTSFNWGVHVPSNPKHVVYVW
IDALVNYISALGYLSDDESLFNKYWPADIHLMAKEIVRFHSIIWPILLMA
LDLPLPKKVFAHGWILMKDGKMSKSKGNVVDPNILIDRYGLDATRYYLMR
ELPFGSDGVFTPEAFVERTNFDLANDLGNLVNRTISMVNKYFDGELPAYQ
GPLHELDEEMEAMALETVKSYTESMESLQFSVALSTVWKFISRTNKYIDE
TTPWVLAKDDSQKDMLGNVMAHLVENIRYAAVLLRPFLTHAPKEIFEQLN
INNPQFMEFSSLEQYGVLNESIMVTGQPKPIFP
3D structure
PDB7wpt Fragment screening and structural analyses highlight the ATP-assisted ligand binding for inhibitor discovery against type 1 methionyl-tRNA synthetase.
ChainA
Resolution2.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.10: methionine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A Y13 Y14 H20 G22 H23 S26 A270 E272 H299 W301 I302 K308 M309 S310 K311 Y13 Y14 H20 G22 H23 S26 A233 E235 H262 W264 I265 K271 M272 S273 K274
BS02 XM0 A Y14 D51 H53 G54 F220 V236 D239 Y14 D51 H53 G54 F183 V199 D202
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004825 methionine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006431 methionyl-tRNA aminoacylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7wpt, PDBe:7wpt, PDBj:7wpt
PDBsum7wpt
PubMed35474479
UniProtQ5HII6|SYM_STAAC Methionine--tRNA ligase (Gene Name=metG)

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