Structure of PDB 7wpn Chain A

Receptor sequence
>7wpnA (length=478) Species: 93062 (Staphylococcus aureus subsp. aureus COL) [Search protein sequence]
KETFYITTPIYYPSGNLHIGHAYSTVAGDVIARYKRMQGYDVRYLTGTDE
HGQKIQEKAQKAGKTEIEYLDEMIAGIKQLWAKLEISNDDFIRTTEERHK
HVVEQVFERLLKQGDIYLGEYLVKEESYFFNISKYTDRLLEFYDQNPDFI
QPPSRKNEMINNFIKPGLADLAVSRTSFNWGVHVPSNPKHVVYVWIDALV
NYISALGYLSDDESLFNKYWPADIHLMAKEIVRFHSIIWPILLMALDLPL
PKKVFAHGWILMKDGKMSKSKGNVVDPNILIDRYGLDATRYYLMRELPFG
SDGVFTPEAFVERTNFDLANDLGNLVNRTISMVNKYFDGELPAYQGPLHE
LDEEMEAMALETVKSYTESMESLQFSVALSTVWKFISRTNKYIDETTPWV
LAKDDSQKDMLGNVMAHLVENIRYAAVLLRPFLTHAPKEIFEQLNINNPQ
FMEFSSLEQYGVLNESIMVTGQPKPIFP
3D structure
PDB7wpn Fragment screening and structural analyses highlight the ATP-assisted ligand binding for inhibitor discovery against type 1 methionyl-tRNA synthetase.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.10: methionine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A Y13 H20 G22 H23 S26 A270 E272 H299 W301 I302 K308 S310 K311 Y11 H18 G20 H21 S24 A228 E230 H257 W259 I260 K266 S268 K269
BS02 29I A I12 Y14 D51 H53 G54 Y235 V236 A240 L241 F276 I10 Y12 D49 H51 G52 Y193 V194 A198 L199 F234
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004825 methionine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006431 methionyl-tRNA aminoacylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7wpn, PDBe:7wpn, PDBj:7wpn
PDBsum7wpn
PubMed35474479
UniProtQ5HII6|SYM_STAAC Methionine--tRNA ligase (Gene Name=metG)

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