Structure of PDB 7wpi Chain A

Receptor sequence
>7wpiA (length=520) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
SAKETFYITTPIYYPSGNLHIGHAYSTVAGDVIARYKRMQGYDVRYLTGT
DEHGQKIQEKAQKAGKTEIEYLDEMIAGIKQLWAKLEISNDDFIRTTEER
HKHVVEQVFERLLKQGDIYLGEYEGWYSVPDETYYTESQLVDPQYENGKI
IGGKSPDSGHEVELVKEESYFFNISKYTDRLLEFYDQNPDFIQPPSRKNE
MINNFIKPGLADLAVSRTSFNWGVHVPSNPKHVVYVWIDALVNYISALGY
LSDDESLFNKYWPADIHLMAKEIVRFHSIIWPILLMALDLPLPKKVFAHG
WILMKDGKMSKSKGNVVDPNILIDRYGLDATRYYLMRELPFGSDGVFTPE
AFVERTNFDLANDLGNLVNRTISMVNKYFDGELPAYQGPLHELDEEMEAM
ALETVKSYTESMESLQFSVALSTVWKFISRTNKYIDETTPWVLAKDDSQK
DMLGNVMAHLVENIRYAAVLLRPFLTHAPKEIFEQLNINNPQFMEFSSLE
QYGVLNESIMVTGQPKPIFP
3D structure
PDB7wpi Fragment screening and structural analyses highlight the ATP-assisted ligand binding for inhibitor discovery against type 1 methionyl-tRNA synthetase.
ChainA
Resolution1.92 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 6.1.1.10: methionine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1V7 A I12 Y14 D51 H53 G54 E132 Y235 V236 W237 A240 L241 Y244 I273 F276 H277 I12 Y14 D51 H53 G54 E132 Y235 V236 W237 A240 L241 Y244 I273 F276 H277
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004825 methionine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006431 methionyl-tRNA aminoacylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7wpi, PDBe:7wpi, PDBj:7wpi
PDBsum7wpi
PubMed35474479
UniProtQ5HII6|SYM_STAAC Methionine--tRNA ligase (Gene Name=metG)

[Back to BioLiP]