Structure of PDB 7wnh Chain A

Receptor sequence
>7wnhA (length=309) Species: 9606 (Homo sapiens) [Search protein sequence]
GLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKR
RRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSSLISALVRAHVDS
NPAMTSLDYSRFQANPDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLP
KADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGE
WIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKI
VNCLKDHVTFNNGGSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAII
DKLFLDTLP
3D structure
PDB7wnh Integrative analysis reveals structural basis for transcription activation of Nurr1 and Nurr1-RXR alpha heterodimer.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A E281 R312 N313 Q316 R319 R341 R342 G343 R344 L345 P346 E21 R52 N53 Q56 R59 R81 R82 G83 R84 L85 P86
BS02 dna A C272 Q273 H274 Y275 V332 R334 G340 R342 G343 R344 C12 Q13 H14 Y15 V72 R74 G80 R82 G83 R84
BS03 ZN A C266 C283 C6 C23
BS04 ZN A C305 C315 C45 C55
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wnh, PDBe:7wnh, PDBj:7wnh
PDBsum7wnh
PubMed36442107
UniProtP43354|NR4A2_HUMAN Nuclear receptor subfamily 4 group A member 2 (Gene Name=NR4A2)

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