Structure of PDB 7wn8 Chain A

Receptor sequence
>7wn8A (length=116) Species: 9606 (Homo sapiens) [Search protein sequence]
QLLFNKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDIYTF
DGALNKSTVPTDFSSAKIEVSQLLKGDASLKMDKSDAVSHTGNYTCEVTE
LTREGETIIELKYRVV
3D structure
PDB7wn8 A pH-dependent anti-CD47 antibody that selectively targets solid tumors and improves therapeutic efficacy and safety.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A K59 E115 K41 E97
BS02 ZN A D80 H108 D62 H90
Gene Ontology
Molecular Function
GO:0070053 thrombospondin receptor activity
Biological Process
GO:0022409 positive regulation of cell-cell adhesion
GO:0050729 positive regulation of inflammatory response
GO:0050766 positive regulation of phagocytosis
Cellular Component
GO:0005886 plasma membrane

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Cellular Component
External links
PDB RCSB:7wn8, PDBe:7wn8, PDBj:7wn8
PDBsum7wn8
PubMed36650558
UniProtQ08722|CD47_HUMAN Leukocyte surface antigen CD47 (Gene Name=CD47)

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