Structure of PDB 7wmn Chain A

Receptor sequence
>7wmnA (length=232) Species: 9606 (Homo sapiens) [Search protein sequence]
HKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDLEAFSHFTKI
ITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPES
ETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQA
VLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKV
TDLRMIGACHASRFLHMKCPTELFPPLFLEVF
3D structure
PDB7wmn Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist.
ChainA
Resolution2.57 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K288 I302 L454 E457 K63 I77 L227 E230
BS02 9IT A F269 F272 T273 I275 I276 R282 M310 M313 S314 R316 L330 N331 L346 M442 F451 P452 F455 F44 F47 T48 I50 I51 R57 M85 M88 S89 R91 L105 N106 L121 M217 F224 P225 F228
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7wmn, PDBe:7wmn, PDBj:7wmn
PDBsum7wmn
PubMed35507418
UniProtP10828|THB_HUMAN Thyroid hormone receptor beta (Gene Name=THRB)

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