Structure of PDB 7wml Chain A

Receptor sequence
>7wmlA (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
KPEPTDEEWELIKTVTEAHVATNAQGWKQKRKFLPKVDLEAFSHFTKIIT
PAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESET
LTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVL
LMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTD
LRMIGACHASRFLHMPTELFPPLFLEVF
3D structure
PDB7wml Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist.
ChainA
Resolution2.67 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K288 E299 I302 K306 L454 E457 K61 E72 I75 K79 L223 E226
BS02 9IQ A F269 F272 I276 A279 R282 M313 S314 R316 L330 N331 L341 G345 L346 I353 H435 R438 F451 F455 F42 F45 I49 A52 R55 M86 S87 R89 L103 N104 L114 G118 L119 I126 H208 R211 F220 F224
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7wml, PDBe:7wml, PDBj:7wml
PDBsum7wml
PubMed35507418
UniProtP10828|THB_HUMAN Thyroid hormone receptor beta (Gene Name=THRB)

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