Structure of PDB 7wmj Chain A

Receptor sequence
>7wmjA (length=229) Species: 9606 (Homo sapiens) [Search protein sequence]
KPEPTDEEWELIKTVTEAHVATNAQGHWKQKRKFLPDLEAFSHFTKIITP
AITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETL
TLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLL
MSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDL
RMIGACHASRFLHMKCPTELFPPLFLEVF
3D structure
PDB7wmj Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist.
ChainA
Resolution2.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K288 Q301 I302 L454 E457 K60 Q73 I74 L224 E227
BS02 9IL A F269 F272 I276 A279 R282 M313 S314 R316 L330 G344 G345 L346 H435 R438 F439 M442 F455 F41 F44 I48 A51 R54 M85 S86 R88 L102 G116 G117 L118 H207 R210 F211 M214 F225
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7wmj, PDBe:7wmj, PDBj:7wmj
PDBsum7wmj
PubMed35507418
UniProtP10828|THB_HUMAN Thyroid hormone receptor beta (Gene Name=THRB)

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