Structure of PDB 7wlx Chain A

Receptor sequence
>7wlxA (length=230) Species: 9606 (Homo sapiens) [Search protein sequence]
KPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPDLEAFSHFTKIIT
PAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESET
LTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVL
LMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTD
LRMIGACHASRFLHMKCPTELFPPLFLEVF
3D structure
PDB7wlx Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist.
ChainA
Resolution2.39 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K288 K306 L454 E457 K61 K79 L225 E228
BS02 9GC A F269 F272 I275 I276 A279 R282 M310 M313 S314 R316 A317 L330 N331 G345 L346 H435 R438 F439 F455 F42 F45 I48 I49 A52 R55 M83 M86 S87 R89 A90 L103 N104 G118 L119 H208 R211 F212 F226
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7wlx, PDBe:7wlx, PDBj:7wlx
PDBsum7wlx
PubMed35507418
UniProtP10828|THB_HUMAN Thyroid hormone receptor beta (Gene Name=THRB)

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