Structure of PDB 7wlj Chain A

Receptor sequence

>7wljA (length=1135) Species: 9606 (Homo sapiens)

TSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKIL
QVFDDFIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEY
SLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLL
CFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDEM
PFICSLSGDNGIMGCHEIPPLKCVNWNRYYNVCRTGSANPHKGAINFDNI
GYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLC
LVVIATQFSETKQREHRLMLRETRAKLRGIVDSKYFNRGIMMAILVNTVS
MGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNI
FDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM
KTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDS
LLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNL
LVAILVEGFQQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIF
LTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSII
DIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSL
KPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAAN
YRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNH
NPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKR
LRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVT
MSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQ
LDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMAT
GMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCE
GMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQ
FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNK

3D structure

• PDB: 7wlj Structure, gating, and pharmacology of human Ca V 3.3 channel.
• Chain: A
• Resolution: 3.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MWV	A	N391 L394 F815 N850 F854 K1379 V1422 L1721	N298 L301 F509 N544 F548 K776 V819 L1118
BS02	CA	A	E357 D1380	E264 D777
BS03	Y01	A	F223 I226 Y373 N374 Y377	F158 I161 Y280 N281 Y284
BS04	Y01	A	V655 H661 L1366	V349 H355 L763
BS05	Y01	A	W837 A838 L840 Y841	W531 A532 L534 Y535
BS06	Y01	A	F372 F375 F1668	F279 F282 F1065
BS07	Y01	A	A1188 L1189 N1663	A585 L586 N1060
BS08	Y01	A	G1367 Q1368 M1371 F1704	G764 Q765 M768 F1101

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0005245 voltage-gated calcium channel activity
• GO:0005261 monoatomic cation channel activity
• GO:0005262 calcium channel activity
• GO:0005515 protein binding
• GO:0008331 high voltage-gated calcium channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0006816 calcium ion transport
• GO:0007165 signal transduction
• GO:0019228 neuronal action potential
• GO:0030431 sleep
• GO:0055085 transmembrane transport
• GO:0070588 calcium ion transmembrane transport
• GO:0098703 calcium ion import across plasma membrane

Cellular Component

• GO:0005886 plasma membrane
• GO:0005891 voltage-gated calcium channel complex
• GO:0016020 membrane
• GO:0034702 monoatomic ion channel complex

External links

• PDB: RCSB:7wlj, PDBe:7wlj, PDBj:7wlj
• PDBsum: 7wlj
• PubMed: 35440630
• UniProt: Q9P0X4|CAC1I_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1I (Gene Name=CACNA1I)