Structure of PDB 7wl0 Chain A

Receptor sequence
>7wl0A (length=214) Species: 9606 (Homo sapiens) [Search protein sequence]
EEEARKVKSGIRQMRLFSQDECAKIEARIDEVVSRAEKGLYNEHTVDRAP
LRNKYFFGEGYTYGAQLQKRGPGQERLYPPGDVDEIPEWVHQLVIQKLVE
HRVIPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSDSALCF
GCKFQFKPIRVSEPVLSLPVRRGSVTVLSGYAADEITHCIRPQDIKERRA
VIILRKTRLDAPRL
3D structure
PDB7wl0 Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.53: mRNA N(6)-methyladenine demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A P128 L129 R130 Y139 G142 P150 E153 I201 V202 S203 H204 V205 D206 P207 F234 I237 T265 P50 L51 R52 Y61 G64 P72 E75 I123 V124 S125 H126 V127 D128 P129 F156 I159 T187
BS02 rna A S112 R276 S34 R198
BS03 MN A H204 D206 H266 H126 D128 H188
Gene Ontology
Molecular Function
GO:0035515 oxidative RNA demethylase activity
Biological Process
GO:0006397 mRNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:7wl0, PDBe:7wl0, PDBj:7wl0
PDBsum7wl0
PubMed35333330
UniProtQ6P6C2|ALKB5_HUMAN RNA demethylase ALKBH5 (Gene Name=ALKBH5)

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