Structure of PDB 7wiw Chain A

Receptor sequence
>7wiwA (length=570) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
SWRAQAASRLLAPLKLPLVLSGVLAALVTLAQLAPFVLLVELSRLLVSGA
GAHRLFTVGFAAVGLLGTGALLAAALTLWLHVIDARFARALRLRLLSKLS
RLPLGWFTSRGSGSIKKLVTDDTLALHYLVTHAVPDAVAAVVAPVGVLVY
LFVVDWRVALVLFGPVLVYLTITSSLTIQSGPRIVQAQRWAEKMNGEAGS
YLEGQPVIRVFGAASSSFRRRLDEYIGFLVAWQRPLAGKKTLMDLATRPA
TFLWLIAATGTLLVATHRMDPVNLLPFMFLGTTFGARLLGIAYGLGGLRT
GLLAARHLQVTLDETELAVREHPREPLDGEAPATVVFDHVTFGYRPGVPV
IQDVSLTLRPGTVTALVGPSGSGKSTLATLLARFHDVERGAIRVGGQDIR
SLAADELYTRVGFVLQEAQLVHGTAAENIALAVPDAPAEQVQVAAREAQI
HDRVLRLPDGYDTVLGANSGLSGGERQRLTIARAILGDTPVLILDQATAF
ADPESEYLVQQALNRLTRDRTVLVIAHRLHTITRADQIVVLDHGRIVERG
THEELLAAGGRYCRLWDTGQ
3D structure
PDB7wiw Cryo-EM structure of Mycobacterium tuberculosis irtAB complexed with ATP in an occluded conformation
ChainA
Resolution3.12 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.2.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A R728 G745 S747 G749 E750 R453 G470 S472 G474 E475
BS02 ATP A Y619 V625 S645 S647 G648 K649 S650 T651 Q691 H802 Y344 V350 S370 S372 G373 K374 S375 T376 Q416 H527
BS03 MG A S650 Q691 S375 Q416
BS04 MG A H356 H402 H407 H81 H127 H132
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0015343 siderophore-iron transmembrane transporter activity
GO:0016491 oxidoreductase activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0071949 FAD binding
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006879 intracellular iron ion homeostasis
GO:0010106 cellular response to iron ion starvation
GO:0033214 siderophore-dependent iron import into cell
GO:0044718 siderophore transmembrane transport
GO:0044847 iron acquisition from host
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wiw, PDBe:7wiw, PDBj:7wiw
PDBsum7wiw
PubMed36882106
UniProtP9WQJ9|IRTA_MYCTU Mycobactin import ATP-binding/permease protein IrtA (Gene Name=irtA)

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