Structure of PDB 7wih Chain A

Receptor sequence
>7wihA (length=741) Species: 9606 (Homo sapiens) [Search protein sequence]
REIKIEGDLVLGGLFPINECGRINEDRGIQRLEAMLFAIDEINKDDYLLP
GVKLGVHILDTCSRDTYALEQSLEFVRASLLIAGVIGGSYSSVSIQVANL
LRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNW
TYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVI
RELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESII
KGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQ
CSLRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCP
NTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGM
GRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPC
APNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCY
DLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRE
LCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKT
NCIARQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNV
KDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIW
LAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKV
3D structure
PDB7wih Structural basis of the activation of metabotropic glutamate receptor 3.
ChainA
Resolution3.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CWY A R68 S149 Y150 A172 Y222 R277 S278 D279 D301 R31 S89 Y90 A112 Y162 R217 S218 D219 D241
Gene Ontology
Molecular Function
GO:0001641 group II metabotropic glutamate receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005246 calcium channel regulator activity
GO:0008066 glutamate receptor activity
GO:0097110 scaffold protein binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007196 adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
GO:0007216 G protein-coupled glutamate receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0010467 gene expression
GO:0033554 cellular response to stress
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0099170 postsynaptic modulation of chemical synaptic transmission
Cellular Component
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030424 axon
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0043197 dendritic spine
GO:0045211 postsynaptic membrane
GO:0097449 astrocyte projection
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wih, PDBe:7wih, PDBj:7wih
PDBsum7wih
PubMed35236939
UniProtQ14832|GRM3_HUMAN Metabotropic glutamate receptor 3 (Gene Name=GRM3)

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