Structure of PDB 7wi7 Chain A

Receptor sequence
>7wi7A (length=565) Species: 9606 (Homo sapiens) [Search protein sequence]
PYKGWKLYFSEVYSDSSPLIEKIQAFEKFFTRHIDLYDKDEIERKGSILV
DFKELTEGGEVTNLIPDIATELRDAPEKTLACMGLAIHQVLTKDLERHAA
ELQAQTMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNI
KPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCPVPVCRGRSFTALRSSP
LTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTI
TGIVKVSNAEEGSRNKNDKCMFLLYIEANSISNSKYAIQEIQANLFKLIV
NSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPG
LGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDFALEAGALVLGDQ
GICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANP
VGGHYNKAKTVSENLKMGSALLSRFDLVFILLHQLLRKYIGYARQYVYPR
LSTEAARVLQDFYLELRKQSTTRQLESLIRLTEARARLELREEATKEDAE
DIVEIMKYSMLGTYS
3D structure
PDB7wi7 Crystal structure of human MCM8/9 complex
ChainA
Resolution6.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C242 C264 C161 C183
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0019899 enzyme binding
GO:0032406 MutLbeta complex binding
GO:0032407 MutSalpha complex binding
GO:0032408 MutSbeta complex binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0007292 female gamete generation
GO:0032508 DNA duplex unwinding
GO:0036298 recombinational interstrand cross-link repair
GO:0048232 male gamete generation
GO:0050821 protein stabilization
GO:0070716 mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
GO:0071168 protein localization to chromatin
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0042555 MCM complex
GO:0097362 MCM8-MCM9 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wi7, PDBe:7wi7, PDBj:7wi7
PDBsum7wi7
PubMed
UniProtQ9UJA3|MCM8_HUMAN DNA helicase MCM8 (Gene Name=MCM8)

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