Structure of PDB 7wgq Chain A

Receptor sequence
>7wgqA (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
HMQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIY
DMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYA
KSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTR
EFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGL
LNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHV
QLLQVIKKTETDMSLHPLLQEIYKDLY
3D structure
PDB7wgq Functional and Structural Insights into Human PPAR alpha / delta / gamma Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate.
ChainA
Resolution2.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K301 L311 V315 L318 K319 P467 L468 E471 K101 L111 V115 L118 K119 P267 L268 E271
BS02 P7F A F264 F282 G284 C285 Q286 R288 S289 H323 I326 Y327 M329 L330 F363 H449 Y473 F64 F82 G84 C85 Q86 R88 S89 H123 I126 Y127 M129 L130 F163 H249 Y273
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wgq, PDBe:7wgq, PDBj:7wgq
PDBsum7wgq
PubMed35563117
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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