Structure of PDB 7wgl Chain A

Receptor sequence
>7wglA (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
DLKAFSKHIYNAYLKNFNMTKKKARSILTGKAPFVIHDIETLWQAEKGLV
WLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLK
YGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFE
FAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEF
HLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLL
QEIYKDM
3D structure
PDB7wgl Functional and Structural Insights into Human PPAR alpha / delta / gamma Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate.
ChainA
Resolution2.091 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 PEM A F246 R248 C249 Q250 T252 T253 H287 H413 M417 Y437 F63 R65 C66 Q67 T69 T70 H104 H230 M234 Y254
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:7wgl, PDBe:7wgl, PDBj:7wgl
PDBsum7wgl
PubMed35563117
UniProtQ03181|PPARD_HUMAN Peroxisome proliferator-activated receptor delta (Gene Name=PPARD)

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