Structure of PDB 7wgi Chain A

Receptor sequence
>7wgiA (length=349) Species: 5059 (Aspergillus flavus) [Search protein sequence]
NETETQKACFKFLDLTSRSFSAVIKELHPELLLPVCVFYLVLRGLDTIED
DTSIPLKTKEPMLREFKDYLEQDGWTFDGNRPEEKDRELLVQFHNVITEF
KNMKPAYREIVKDITDKMGNGMADYCRKAEFEDASVKTIEEYDLYCYYVA
GLVGEGLTRLFVEAEFGNPALLSRPRLHKSMGLFLQKTNIIRDVREDHDD
DRHFWPKEIWSKYVTEFEDLFKPENRETALNCGSEMVLNALEHAEECLFY
LAGLREQSVFNFCAIPQAMAIATLELCFRNPDMFDRNIKITKGEACQLMM
ESTQNLHVLCDTFRRYARRIHKKNTPKDPNFLKISIVCGKIEKFIDTIF
3D structure
PDB7wgi A Structural and Bioinformatics Investigation of a Fungal Squalene Synthase and Comparisons with Other Membrane Proteins.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.21: squalene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IND A G189 L192 M216 L220 G154 L157 M181 L185
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0051996 squalene synthase [NAD(P)H] activity
Biological Process
GO:0006696 ergosterol biosynthetic process
GO:0008610 lipid biosynthetic process
GO:0009058 biosynthetic process
GO:0016126 sterol biosynthetic process
GO:0045338 farnesyl diphosphate metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wgi, PDBe:7wgi, PDBj:7wgi
PDBsum7wgi
PubMed35811857
UniProtA0A364LX79

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