Structure of PDB 7wfc Chain A

Receptor sequence
>7wfcA (length=309) Species: 290028 (Human coronavirus HKU1) [Search protein sequence]
KIDVLLTVDGVNFKSISLTVGEVFGKILGNVFCDGIDVTKLKCSDFYADK
ILYQYENLSLADISAVQSSFGFDQQQLLAYYNFLTVCKWSVVVNGPFFSF
EQSHNNSYVNVACLMLQHINLKFNKWQWQEAWYEFRAGRPHRLVALVLAK
GHFKFDEPSDATDFIRVVLKQADLSGAICELELICDCGIKQESRVGVDAV
MHFGTLAKTDLFNGYKIGCNCAGRIVHCTKLNVPFLICSNTPLSKDLPDD
VVAANMFMGVGVGHYTHLKCGSPYQHYDACSVKKYTGVSGCLTDCLYLKN
LTQTFTSML
3D structure
PDB7wfc The substrate selectivity of papain-like proteases from human-infecting coronaviruses correlates with innate immune suppression.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.50: mRNA guanylyltransferase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C187 C221 C223 C185 C219 C221
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7wfc, PDBe:7wfc, PDBj:7wfc
PDBsum7wfc
PubMed37130166
UniProtU3N841

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