Structure of PDB 7wf5 Chain A

Receptor sequence
>7wf5A (length=261) Species: 9031 (Gallus gallus) [Search protein sequence]
KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA
FLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGK
YLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFG
LFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVL
DQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTS
TEPQYQPGENL
3D structure
PDB7wf5 Structural study of ponatinib in inhibiting SRC kinase.
ChainA
Resolution1.798 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0LI A L273 A293 K295 E310 M314 V323 T338 Y340 M341 V383 H384 L393 V402 A403 D404 F405 L17 A37 K39 E54 M58 V67 T82 Y84 M85 V127 H128 L137 V146 A147 D148 F149
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7wf5, PDBe:7wf5, PDBj:7wf5
PDBsum7wf5
PubMed35151199
UniProtP00523|SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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