Structure of PDB 7wex Chain A

Receptor sequence
>7wexA (length=382) Species: 227882 (Streptomyces avermitilis MA-4680 = NBRC 14893) [Search protein sequence]
DPAEGLLADPYAVYDRLRDTAPVHRIAGTDGKPAWLVTRYDDVREGLANP
LLSLDKKHALPGNYRGLALPPALDANLLNMDAPDHTRIRRLVGRAFTLRR
VEQLREPVRETAHRLLDALGTHGSTDLIASYAAPLPITVICDLLGVPDEH
RRDFRAWTDPLVTPDPARPDVARESVVSLLGFFTGLLADKRKNPADDLLS
DLIAVQLTEDELMSLAFLILFAGYENTVHLIGNAVLALLRHPEQLAALRE
DPARLPDAVGEFARYEGPALLAIRRFPVRDVTIGGVTVPAGETVLLSLSA
ANRDPSRFPDPDRLDLGRDAAGHLALGHGVHYCLGAPLARLETEVALAAL
LERFPDLALAETEPRRRPSLRARGLLALPVTY
3D structure
PDB7wex The 16 alpha-Hydroxylation of Progesterone by Cytochrome P450 107X1 from Streptomyces avermitilis.
ChainA
Resolution1.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A L78 L79 H86 R90 A228 G229 N232 T233 P274 I279 R281 A331 L332 H337 C339 L340 G341 L344 A345 L77 L78 H85 R89 A222 G223 N226 T227 P268 I273 R275 A325 L326 H331 C333 L334 G335 L338 A339
BS02 GOL A N232 L277 N226 L271
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:7wex, PDBe:7wex, PDBj:7wex
PDBsum7wex
PubMed35426465
UniProtQ82A10

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