Structure of PDB 7wel Chain A

Receptor sequence

>7welA (length=1102) Species: 9606 (Homo sapiens)

HSWFSLFITVTILVNCVCMTRTDLPEKIEYVFTVIYTFEALIKILARGFD
PWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVG
ALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAYSSHR
KPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFA
WAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLIL
AVVTMAYEEQNQATWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEH
HGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCII
VTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGA
LGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFF
HSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFI
ALLLNSFFADVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYL
DQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIV
NISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVG
AIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIV
NNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAA
VDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKK
KLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQ
AFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMK
MFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIR
LARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM
SSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPP
YCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFN
VA

3D structure

• PDB: 7wel Structural basis for high-voltage activation and subtype-specific inhibition of human Na v 1.8.
• Chain: A
• Resolution: 3.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	95T	A	Q355 F382 T1659 F1710 M1713 M1716	Q212 F239 T1033 F1084 M1087 M1090
BS02	CLR	A	L393 T397 F885 V1414 I1418 V1714 Y1717	L250 T254 F499 V788 I792 V1088 Y1091
BS03	CLR	A	T679 S769 W770 L1286 I1290	T293 S383 W384 L660 I664
BS04	LPE	A	F382 P1605 F1608	F239 P979 F982
BS05	LPE	A	Y373 I375 F376 S1568 T1570	Y230 I232 F233 S942 T944
BS06	CLR	A	K728 I735 F758	K342 I349 F372
BS07	LPE	A	A1170 F1171 L1616 F1647	A544 F545 L990 F1021
BS08	LPE	A	I680 S690 T692	I294 S304 T306
BS09	CLR	A	M1494 V1495	M868 V869
BS10	P5S	A	W344 F350 K863 L871	W201 F207 K477 L485
BS11	P5S	A	W1292 N1352 A1354 M1355 L1361 P1695 A1696 I1699 I1707	W666 N726 A728 M729 L735 P1069 A1070 I1073 I1081

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0005248 voltage-gated sodium channel activity
• GO:0005261 monoatomic cation channel activity
• GO:0005272 sodium channel activity
• GO:0044325 transmembrane transporter binding
• GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

Biological Process

• GO:0002027 regulation of heart rate
• GO:0006811 monoatomic ion transport
• GO:0006814 sodium ion transport
• GO:0007600 sensory perception
• GO:0034220 monoatomic ion transmembrane transport
• GO:0034765 regulation of monoatomic ion transmembrane transport
• GO:0035725 sodium ion transmembrane transport
• GO:0042475 odontogenesis of dentin-containing tooth
• GO:0055085 transmembrane transport
• GO:0055117 regulation of cardiac muscle contraction
• GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization
• GO:0086002 cardiac muscle cell action potential involved in contraction
• GO:0086010 membrane depolarization during action potential
• GO:0086016 AV node cell action potential
• GO:0086043 bundle of His cell action potential
• GO:0099505 regulation of presynaptic membrane potential

Cellular Component

• GO:0001518 voltage-gated sodium channel complex
• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0030424 axon
• GO:0034702 monoatomic ion channel complex
• GO:0042734 presynaptic membrane
• GO:0070062 extracellular exosome
• GO:0071439 clathrin complex
• GO:0098978 glutamatergic synapse

External links

• PDB: RCSB:7wel, PDBe:7wel, PDBj:7wel
• PDBsum: 7wel
• PubMed: 35858452
• UniProt: Q9Y5Y9|SCNAA_HUMAN Sodium channel protein type 10 subunit alpha (Gene Name=SCN10A)