Structure of PDB 7wc9 Chain A

Receptor sequence
>7wc9A (length=358) Species: 562,9606 [Search protein sequence]
LQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTAKIWHLCAIS
LDRYVAIQNPSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSC
LLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAADLEDNWETLND
NLKVIEKADNAAQVKDALTKMRAAALDADILVGQIDDALKLANEGKVKEA
QAAAEQLKTTINAYIQKYGQSISNEQKACKVLGIVFFLFVVMWCPFFITN
IMAVICKESCNEDVIGALLNVFVWIGYLNSAVNPLVYTLFNKTYRSAFSR
YIQCQYKE
3D structure
PDB7wc9 Structure-based discovery of nonhallucinogenic psychedelic analogs.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A E1008 D1012 E196 D200
BS02 CLR A I341 T342 I358 L361 I298 T299 I315 L318
BS03 CLR A A90 I93 M97 Y394 Y399 A20 I23 M27 Y351 Y356
BS04 93F A D155 L229 F243 F332 W336 F339 F340 N343 L362 Y370 D85 L152 F166 F289 W293 F296 F297 N300 L319 Y327
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wc9, PDBe:7wc9, PDBj:7wc9
PDBsum7wc9
PubMed35084960
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P28223|5HT2A_HUMAN 5-hydroxytryptamine receptor 2A (Gene Name=HTR2A)

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