Structure of PDB 7wbu Chain A

Receptor sequence

>7wbuA (length=898) Species: 9913 (Bos taurus)

QKINPYRSHMKQKFQVLWEKEPCLLVPEDFYEETTKIEYELLSTVYLDAS
SPTVVLHGPEGIGKTTFLRKVMLEWAKGNLWRDRFSFVFFLTGREMNGVT
DMSLVELLSRDWPESSEPIEDIFSQPERILFILDGMEELKFDLDCNADLC
EDWEQPQSMQVVLQSLLQKQMLPECSLLLALSKMGMRKNYSLLKHMKCIF
LLGFSEHQRKLYFSHYFQEKDASSRAFSFVREKSSLFVLCQSPFLCWLVC
TSLKCQLEKGEDLELDSETITGLYVSFFTKVFRSGSETCPLKQRRARLKS
LCTLAAEGMWTCTFLFCPEDLRRNGVSESDTSMWLDMKLLHRSGDCLAFI
HTCIQEFCAAMFYMFTRPKDPPHSVIGNVTQLITRAVSGHYSRLSWTAVF
LFVFSTERMTHRLETSFGFPLSKEIKQEITQSLDTLSQCDPNNVMMSFQA
LFNCLFETQDPEFVAQVVNFFKDIDIYIGTKEELIICAACLRHCHSLQKF
HLCMEHVFPDESGCISNTIEKLTLWRDVCSAFAASEDFEILNLDNCRFDE
PSLAVLCRTLSQPVCKLRKFVCNFASNLANSLELFKVILHNPHLKHLNFY
GSSLSHMDARQLCEALKHPMCNIEELMLGKCDITGEACEDIASVLVHNKK
LNLLSLCENALKDDGVLVLCEALKNPDCALEALLLSHCCFSSAACDHLSQ
VLLYNRSLTFLDLGSNVLKDEGVTTLCESLKHPSCNLQELWLMNCYFTSV
CCVDIATVLIHSEKLKTLKLGNNKIYDAGAKQLCKALKHPKCKLENLGLE
ACELSPASCEDLASALTTCKSLTCVNLEWITLDYDGAAVLCEALVSLECS
LQLLGLNKSSYDEEIKMMLTQVEEMNPNLIISHHLWTDDEGRRRGILV

3D structure

• PDB: 7wbu The structure of NLRP9 reveals a unique C-terminal region with putative regulatory function.
• Chain: A
• Resolution: 3.42 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	A	V119 Y124 G159 I160 G161 K162 T163 T164 F302 P341 H449	V26 Y31 G61 I62 G63 K64 T65 T66 F204 P243 H351

Gene Ontology

Molecular Function

• GO:0005524 ATP binding

Biological Process

• GO:0006954 inflammatory response
• GO:0045087 innate immune response
• GO:0050727 regulation of inflammatory response

Cellular Component

• GO:0005737 cytoplasm
• GO:0061702 canonical inflammasome complex

External links

• PDB: RCSB:7wbu, PDBe:7wbu, PDBj:7wbu
• PDBsum: 7wbu
• PubMed: 35090055
• UniProt: Q288C4|NLRP9_BOVIN NACHT, LRR and PYD domains-containing protein 9 (Gene Name=NLRP9)