Structure of PDB 7w7x Chain A

Receptor sequence
>7w7xA (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEMEVEEF
LKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQ
EVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFG
LSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIA
TYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDR
PSFAEIHQAFETMFQES
3D structure
PDB7w7x Cell-Active, Reversible, and Irreversible Covalent Inhibitors That Selectively Target the Catalytic Lysine of BCR-ABL Kinase.
ChainA
Resolution2.00001 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8DW A L248 G249 Y253 A269 K271 I313 T315 E316 M318 G321 L370 F382 L17 G18 Y22 A38 K40 I80 T82 E83 M85 G88 L137 F149
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7w7x, PDBe:7w7x, PDBj:7w7x
PDBsum7w7x
PubMed35438229
UniProtP00519|ABL1_HUMAN Tyrosine-protein kinase ABL1 (Gene Name=ABL1)

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