Structure of PDB 7w7l Chain A

Receptor sequence
>7w7lA (length=294) Species: 9606 (Homo sapiens) [Search protein sequence]
ETADGPYLVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKI
CNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGICAVSVGPKDMTAQ
FNNLGVLHVTKKNMMGTMIQKLQRQRLRSRPQGLTEAEQRELEQEAKELK
KVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDSKSPGASNLKISR
MDKTAGSVRGGDEVYLLCDKVQKDDIEVRFYEDDENGWQAFGDFSPTDVH
KQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYY
3D structure
PDB7w7l Structures of NF-kappa B p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation.
ChainA
Resolution3.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R52 Y55 C57 T142 R20 Y23 C25 T110
BS02 dna A R52 R54 H62 G63 K75 K221 R20 R22 H30 G31 K43 K189
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7w7l, PDBe:7w7l, PDBj:7w7l
PDBsum7w7l
PubMed36779700
UniProtQ00653|NFKB2_HUMAN Nuclear factor NF-kappa-B p100 subunit (Gene Name=NFKB2)

[Back to BioLiP]