Structure of PDB 7w6x Chain A

Receptor sequence
>7w6xA (length=447) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
MLSFLWDLASFIVALGVLITVHEFGHFWVARRCGVRVERFSIGFGKALWR
RTDKLGTEYVIALIPLGGYVKMLDERAEPVVPELRHHAFNNKSVGQRAAI
IAAGPVANFIFAIFAYWLVFIIGVPGVRPVVGEIAANSIAAEAQIAPGTE
LKAVDGIETPDWDAVRLQLVDKIGDESTTITVAPFGSDQRRDVKLDLRHW
AFEPDKEDPVSSLGIRPRGPQIEPVLENVQPNSAASKAGLQAGDRIVKVD
GQPLTQWVTFVMLVRDNPGKSLALEIERQGSPLSLTLIPESKPGNGKAIG
FVGIEPKVIPLPDEYKVVRQYGPFNAIVEATDKTWQLMKLTVSMLGKLIT
GDVKLNNLSGPISIAKGAGMTAELGVVYYLPFLALISVNLGIINLFPLPV
LDGGHLLFLAIEKIKGGPVSERVQDFCYRIGSILLVLLMGLALFNDF
3D structure
PDB7w6x Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H22 H26 D402 H22 H26 D402
BS02 BAT A I19 H22 E23 H26 F44 L66 G68 N394 D402 I19 H22 E23 H26 F44 L66 G68 N394 D402
BS03 ZN A H86 H87 H86 H87
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0043856 anti-sigma factor antagonist activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0036460 cellular response to cell envelope stress
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7w6x, PDBe:7w6x, PDBj:7w6x
PDBsum7w6x
PubMed36001659
UniProtP0AEH1|RSEP_ECOLI Regulator of sigma-E protease RseP (Gene Name=rseP)

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