Structure of PDB 7w5r Chain A

Receptor sequence
>7w5rA (length=155) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVL
VGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREI
RKHKE
3D structure
PDB7w5r Structural basis of the oncogenic KRAS mutant and GJ101 complex.
ChainA
Resolution3.87 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 GDP A V12 G13 V14 G15 K16 F28 D30 E31 V12 G13 V14 G15 K16 F28 D30 E31
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7w5r, PDBe:7w5r, PDBj:7w5r
PDBsum7w5r
PubMed36516586
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

[Back to BioLiP]