Structure of PDB 7w5j Chain A

Receptor sequence
>7w5jA (length=340) Species: 63577 (Trichoderma atroviride) [Search protein sequence]
TLSGERREIIRRALNKKILVPNILELMPAWPSEFQPNIDEVNVEIDEWLK
TVNVAKEKKLKHRARGNYTLLAGIYYPHCRKEKMLALSQFLYWIFFWDDE
IDREGTILCCAETNKCINDCLGPEPNYTPPPGSRGTVEMLYPILRDLRAG
LSPVSTMRLKQELHDYVNGVKNQHLPNPWDHFQMRVDDVGVIPSITQNEY
AMDFTLPDWIRRHEAMEEIVLQCTKLTILLNEILSLQKEFRVSQLENLCL
LFMNTYDMSIEQSIHKVLGLLKDHYKICIEAEARLPWSTTDEKLNNNIRE
YIRGCQRLATGTACWSYNCERYFKLSQLNDQQELLLDLSR
3D structure
PDB7w5j Structural insights into the cyclization of unusual brasilane-type sesquiterpenes.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.3.-
4.2.3.104: alpha-humulene synthase.
4.2.3.137: (E)-2-epi-beta-caryophyllene synthase.
4.2.3.157: (+)-isoafricanol synthase.
4.2.3.182: pristinol synthase.
4.2.3.57: (-)-beta-caryophyllene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAR A Y105 F125 D128 G235 Y75 F95 D98 G190
BS02 POP A R230 N276 S280 E284 R366 Y367 R185 N231 S235 E239 R321 Y322
BS03 MG A N276 S280 E284 N231 S235 E239
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0080016 (-)-E-beta-caryophyllene synthase activity
GO:0080017 alpha-humulene synthase activity

View graph for
Molecular Function
External links
PDB RCSB:7w5j, PDBe:7w5j, PDBj:7w5j
PDBsum7w5j
PubMed35504416
UniProtA0A5S9I252|TATC6_HYPAT Terpene cyclase 6 (Gene Name=tatc6)

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