Structure of PDB 7w39 Chain A

Receptor sequence
>7w39A (length=394) Species: 9606 (Homo sapiens) [Search protein sequence]
TYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQS
EQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMR
VGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLRE
VVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIR
VIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGA
GGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDR
KIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVC
TEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN
3D structure
PDB7w39 USP14-regulated allostery of the human proteasome by time-resolved cryo-EM.
ChainA
Resolution3.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A P218 G219 T220 G221 K222 T223 L224 I354 H358 G382 P179 G180 T181 G182 K183 T184 L185 I315 H319 G343
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
Biological Process
GO:0001649 osteoblast differentiation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0000932 P-body
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0022624 proteasome accessory complex
GO:0034774 secretory granule lumen
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:1904813 ficolin-1-rich granule lumen

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7w39, PDBe:7w39, PDBj:7w39
PDBsum7w39
PubMed35477760
UniProtP35998|PRS7_HUMAN 26S proteasome regulatory subunit 7 (Gene Name=PSMC2)

[Back to BioLiP]