Structure of PDB 7vzs Chain A

Receptor sequence

>7vzsA (length=566) Species: 5062 (Aspergillus oryzae)

TTTYDYIVVGGGTSGLVVANRLSENPDVSVLLLEAGASVFNNPDVTNANG
YGLAFGSAIDWQYQSINQSYAGGKQQVLRAGKALGGTSTINGMAYTRAED
VQIDVWQKLGNEGWTWKDLLPYYLKSENLTAPTSSQVAAGAAYNPAVNGK
EGPLKVGWSGSLASGNLSVALNRTFQAAGVPWVEDVNGGKMRGFNIYPST
LDVDLNVREDAARAYYFPYDDRKNLHLLENTTANRLFWKNGSAEEAIADG
VEITSADGKVTRVHAKKEVIISAGALRSPLILELSGVGNPTILKKNNITP
RVDLPTVGENLQDQFNNGMAGEGYGVLAGASTVTYPSISDVFGNETDSIV
ASLRSQLSDYAAATVKVSNGHMKQEDLERLYQLQFDLIVKDKVPIAEILF
HPGGGNAVSSEFWGLLPFARGNIHISSNDPTAPAAINPNYFMFEWDGKSQ
AGIAKYIRKILRSAPLNKLIAKETKPGLSEIPATAADEKWVEWLKANYRS
NFHPVGTAAMMPRSIGGVVDNRLRVYGTSNVRVVDASVLPFQVCGHLVST
LYAVAERASDLIKEDA

3D structure

• PDB: 7vzs Conformational change of catalytic residue in reduced enzyme of FAD-dependent Glucose Dehydrogenase at pH6.5
• Chain: A
• Resolution: 1.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G13 G15 T16 S17 E37 A38 Y54 F58 W64 R82 G84 G89 T90 N94 G95 M96 A97 T235 A236 A276 G277 R280 F505 A539 H549 L550 V551 L554	G10 G12 T13 S14 E34 A35 Y51 F55 W61 R79 G81 G86 T87 N91 G92 M93 A94 T232 A233 A273 G274 R277 F502 A536 H546 L547 V548 L551
BS02	DGO	A	Y54 E414 R502 N504 H549	Y51 E411 R499 N501 H546
BS03	DGO	A	I352 Q359 E447 W448 K451	I349 Q356 E444 W445 K448
BS04	DGO	A	Y9 L25 N28 K566 A569	Y6 L22 N25 K563 A566

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0016491 oxidoreductase activity
• GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
• GO:0050660 flavin adenine dinucleotide binding

External links

• PDB: RCSB:7vzs, PDBe:7vzs, PDBj:7vzs
• PDBsum: 7vzs
• UniProt: A0A1S9DW10