Structure of PDB 7vyx Chain A

Receptor sequence

>7vyxA (length=1211) Species: 2565572 (Parasutterella muris)

HLHLISAKASRKYRRTIACLSDTAKKDLERRKQSGAADPAQELSCLKTIK
FKLEVPEGSKLPSFDRISQIYNALETIEKGSLSYLLFALILSGFRIFPNS
SAAKTFASSSCYKNDQFASQIKEIFGEMVKNFIPSELESILKKGRRKNNK
DWTEENIKRVLNSEFGRKNSEGSSALFDSFLSKFSQELFRKFDSWNEVNK
KYLEAAELLDSMLASYGPFDSVCKMIGDSDSRNSLPDKSTIAFTNNAEIT
VDIESSVMPYMAIAALLREYRQSKSKAAPVAYVQSHLTTTNGNGLSWFFK
FGLDLIRKAPVSSGSKSLQELFSVPDDKLDGLKFIKEACEALPEASLLCG
EKGELLGYQDFRTSFAGHIDSWVANYVNRLFELIELVNQSHSLELFEGLV
KNVRQTLKKLAGIDISSSPNEQDIKEFYAFSDVLNRLGSIRNQIENAVKK
LKKLPKLNGLGGGVPKQQELLDKALESVKQIRHYQRIDFERVIQWAVNEH
CLETVPKFLVDAEKKKINKESSTDFAAKENAVRFLLEGIGAAARGKTDSV
SKAAYNWFVVNNFLAKKDLNRYFINCQGCIYKPPYSKRRSLAFALRSDNK
DTIEVVWEKFETFYKEISKEIEKFNIFSQEFQTFLHLENLRMKLLLRRIQ
KPIPAEIAFFSLPQEYYDSLPPNVAFLNQEITPSEYITQFNLYSSFLNGN
LILLRRSRSYLRAKFSWVGNSKLIYAAKEARLWKIPNAYWKSDEWKMILD
SNVLVFDKAGNVLPAPTLKKVCEREGDLRLFYPLLRQLPHDWCYRNPFVK
SVGREKNVIEVNKEGEPKVASALPGSLFRLIGPAPFKSLLDDCFFNPLDK
DLRECMLIVDQEISQKVEAQKVEASLESCTYSIAVPIRYHLEEPKVSNQF
ENVLAIAQGEAGLAYAVFSLKSIGEAETKPIAVGTIRIPSIRRLIHSVST
YRKKKQRLQNFKQNYDSTAFIMRENVTGDVCAKIVGLMKEFNAFPVLEYD
VSRQLSAVYKAVNSHFLYFKEPGRDALRKQLWYGGDSWTIDGIEIVTRER
KEDGKEGVEKIVPLKVFPGRSVSARFTSKTCSCCGRNVFDWLFTEKKAFN
VNSKGELTTADGVIQLFEADRSKGPKFYARRKERTPLTKPIAKGSYSLEE
IERRVRTNLRRAPKSKQSRDTSQSQYFCVYKDCALHFSGMQADENAAINI
GRRFLTALRKN

3D structure

• PDB: 7vyx Structural insights into target DNA recognition and cleavage by the CRISPR-Cas12c1 system
• Chain: A
• Resolution: 3.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	H7 H9 S12 A13 K14 R20 L52 K53 T54 K56 K58 R391 P515 K516 N518 G519 N630 R631 N635 R774 K776 R793 W795 K796 P798 A800 Y801 S804 Q849 P851 H852 R891 I893 G894 P895 A896 P897 F898 S900 M918 R1005 R1019 K1024 N1037 D1041 R1071 Q1098 R1204 S1238 Q1240 S1241 R1242	H1 H3 S6 A7 K8 R14 L46 K47 T48 K50 K52 R379 P455 K456 N458 G459 N570 R571 N575 R712 K714 R731 W733 K734 P736 A738 Y739 S742 Q787 P789 H790 R829 I831 G832 P833 A834 P835 F836 S838 M856 R943 R957 K962 N975 D979 R1003 Q1030 R1131 S1165 Q1167 S1168 R1169
BS02	dna	A	R152 K153 K156 T375 G379 S383 N387 T750 K875 R915 E916 R1035 P1090	R146 K147 K150 T363 G367 S371 N375 T688 K813 R853 E854 R973 P1022
BS03	dna	A	Q47 N105 S106 G150 R151 R152 N155 N299 W303 F307 R374	Q41 N99 S100 G144 R145 R146 N149 N293 W297 F301 R362
BS04	ZN	A	C1152 C1251 C1256	C1084 C1178 C1183

External links

• PDB: RCSB:7vyx, PDBe:7vyx, PDBj:7vyx
• PDBsum: 7vyx