Structure of PDB 7vyp Chain A

Receptor sequence

>7vypA (length=674) Species: 1912 (Streptomyces hygroscopicus)

MLVLGLNGNFSAADTDVVPQLGEVFFHDSAASLIRDGELVAAVEEERLNR
IKKTTKFPLNAVRECLALAGARPEDVDAVGYYFPENHIDTVLNHLYTEYP
RAPLRYSRELIRQRLKEGLGWDLPDEKLVYVPHHEAHAYSSYLHSGMDSA
LVLVLDGRGELHSGTVYRAEGTRLEKLADYPVPKSLGGLYLNATYLLGYG
FGDEYKVMGLAPWGNPETYRDTFAKLYTLQDNGEYELHGNIMVPNLVSPL
FYAEGFRPRRKGEPFTQAHRDFAAALQETVEKIVLHILEYWAKTSGHSRL
CFGGGVAHNSSLNGLILKSGLFDEVFVHPASHDAGAGEGAAYAAAASLGT
LERPGKRLLSASLGPALGGREQIRARLADWAPLIDVEFPDDAVETAAGLL
AEGQVLGWAYGRSEFGPRALGHRSIVADARPEENRTRINAMVKKREGFRP
FAPVVTAEAARDYFDLSGADGNHEFMSFVVPVLPERRTELGAVTHVDGTA
RVQVVSAESGERFHRLVRRFGELTGTPVLLNTSFNNNAEPIVQSLDDVVT
SFLTTDLDVLVVEDCLVRGKASPDLGVLVPRFRPVTRLVERRTAGPDASA
GAKTHEIHLDYDGGPSAKVSPELYELLGAVDGTTTLGDLAKTVGGLSDAL
ATEVFALWEQRFLTLAPAGDIGPL

3D structure

• PDB: 7vyp Endowing homodimeric carbamoyltransferase GdmN with iterative functions through structural characterization and mechanistic studies.
• Chain: A
• Resolution: 2.88 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FE	A	H133 H137 D156 D333	H133 H137 D156 D333
BS02	CP	A	Y205 K443 R445 R449 N535	Y205 K443 R445 R449 N535
BS03	82Z	A	V24 F25 H27 H87 G157 R158 L191 F201 D333	V24 F25 H27 H87 G157 R158 L191 F201 D333
BS04	AMP	A	H137 D156 G157 G187 Y190 E204 G305 N309 H332 D333	H137 D156 G157 G187 Y190 E204 G305 N309 H332 D333
BS05	8CW	A	M242 V243 P244	M242 V243 P244

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0005524 ATP binding
• GO:0046872 metal ion binding

Biological Process

• GO:0009058 biosynthetic process

External links

• PDB: RCSB:7vyp, PDBe:7vyp, PDBj:7vyp
• PDBsum: 7vyp
• PubMed: 36329057
• UniProt: Q84G19