Structure of PDB 7vxg Chain A

Receptor sequence
>7vxgA (length=477) Species: 9606 (Homo sapiens) [Search protein sequence]
SRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVT
HIKIQNTGDYYDLYGGEKFATLAELVQYYMEHIELKYPLNCADPTSERWF
HLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDSKVTHVMIRC
QELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAA
EIESRVRELSKGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILP
FDHTRVVLHDGDPEPVSDYINANIIMPKSYIATQGCLQNTVNDFWRMVFQ
ENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYT
LRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQE
SIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIRKGVDCDIDVPKTIQMVR
SQRSGMVQTEAQYRFIYMAVQHYIETL
3D structure
PDB7vxg SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 83Q A T108 S109 E110 R111 F113 E249 E250 T253 L254 P491 K492 Q495 T95 S96 E97 R98 F100 E215 E216 T219 L220 P443 K444 Q447
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7vxg, PDBe:7vxg, PDBj:7vxg
PDBsum7vxg
PubMed35310939
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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