Structure of PDB 7vw6 Chain A

Receptor sequence

>7vw6A (length=913) Species: 272630 (Methylorubrum extorquens AM1)

TIAFEFDGQQVEAQPGETIWAVAKRLGTHIPHLCHKPDPGYRPDGNCRAC
MVEIEGERVLAASCKRTPAIGMKVKSATERATKARAMVLELLVADQPERA
TSHDPSSHFWVQADVLDVTESRFPAAERWTSDVSHPAMSVNLDACIQCNL
CVRACREVQVNDVIGMAYRAAGSKVVFDFDDPMGGSTCVACGECVQACPT
GALMPAAYLDANQTRTVYPDREVKSLCPYCGVGCQVSYKVKDERIVYAEG
VNGPANQNRLCVKGRFGFDYVHHPHRLTVPLIRLENVPKDANDQVDPANP
WTHFREATWEEALDRAAGGLKAIRDTNGRKALAGFGSAKGSNEEAYLFQK
LVRLGFGTNNVDHCTRLCHASSVAALMEGLNSGAVTAPFSAALDAEVIVV
IGANPTVNHPVAATFLKNAVKQRGAKLIIMDPRRQTLSRHAYRHLAFRPG
SDVAMLNAMLNVIVTEGLYDEQYIAGYTENFEALREKIVDFTPEKMASVC
GIDAETLREVARLYARAKSSLIFWGMGVSQHVHGTDNSRCLIALALITGQ
IGRPGTGLHPLRGQNNVQGASDAGLIPMVYPDYQSVEKDAVRELFEEFWG
QSLDPQKGLTVVEIMRAIHAGEIRGMFVEGENPAMSDPDLNHARHALAML
DHLVVQDLFLTETAFHADVVLPASAFAEKAGTFTNTDRRVQIAQPVVAPP
GDARQDWWIIQELARRLDLDWNYGGPADIFAEMAQVMPSLNNITWERLER
EGAVTYPVDAPDQPGNEIIFYAGFPTESGRAKIVPAAIVPPDEVPDDEFP
MVLSTGRVLEHWHTGSMTRRAGVLDALEPEAVAFMAPKELYRLGLRPGGS
MRLETRRGAVVLKVRSDRDVPIGMIFMPFCYAEAAANLLTNPALDPLGKI
PEFKFCAARVVPA

3D structure

• PDB: 7vw6 Multiple electron transfer pathways of tungsten-containing formate dehydrogenase in direct electron transfer-type bioelectrocatalysis.
• Chain: A
• Resolution: 2.19 Å

Enzymatic activity

• Enzyme Commision number: 1.17.1.9: formate dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SF4	A	C213 I214 Q215 C216 N217 C219 V243 C266 P267 T268 A270 L271	C145 I146 Q147 C148 N149 C151 V175 C198 P199 T200 A202 L203
BS02	SF4	A	C223 N229 V231 I232 C256 V257 A258 C259 G260 C262	C155 N161 V163 I164 C188 V189 A190 C191 G192 C194
BS03	FES	A	H100 C102 H103 G113 C115 R116 C118 C132	H32 C34 H35 G45 C47 R48 C50 C64
BS04	SF4	A	C295 C298 C302 C329 K331 G332 V479	C227 C230 C234 C261 K263 G264 V411
BS05	MGD	A	K407 C432 C436 Q598 G698 N700 S704 Q724 D725 L726 T873 R875 H881 T882 M885 F947 N955 F971	K339 C364 C368 Q530 G630 N632 S636 Q656 D657 L658 T805 R807 H813 T814 M817 F879 N887 F903
BS06	MGD	A	K331 G470 N472 N476 D499 P500 R501 F515 G518 D520 G593 M594 G595 H599 G631 Q632 R875 V876 L877 H879 W880 H881 K972	K263 G402 N404 N408 D431 P432 R433 F447 G450 D452 G525 M526 G527 H531 G563 Q564 R807 V808 L809 H811 W812 H813 K904

Gene Ontology

Molecular Function

• GO:0008863 formate dehydrogenase (NAD+) activity
• GO:0016491 oxidoreductase activity
• GO:0043546 molybdopterin cofactor binding
• GO:0046872 metal ion binding
• GO:0051536 iron-sulfur cluster binding
• GO:0051537 2 iron, 2 sulfur cluster binding
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:0015942 formate metabolic process
• GO:0045333 cellular respiration

Cellular Component

• GO:1990204 oxidoreductase complex

External links

• PDB: RCSB:7vw6, PDBe:7vw6, PDBj:7vw6
• PDBsum: 7vw6
• PubMed: 35535582
• UniProt: C5ATT7