Structure of PDB 7vv8 Chain A

Receptor sequence
>7vv8A (length=167) Species: 9606 (Homo sapiens) [Search protein sequence]
SMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TCLLDILDTAGLEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQ
IKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTR
QGVEDAFYTLVREIRQH
3D structure
PDB7vv8 Structural insights into Ras regulation by SIN1.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A G13 G15 K16 S17 A18 F28 V29 D30 Y32 P34 T35 G60 N116 K117 D119 S145 A146 G14 G16 K17 S18 A19 F29 V30 D31 Y33 P35 T36 G61 N117 K118 D120 S146 A147
BS02 MG A S17 T35 S18 T36
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vv8, PDBe:7vv8, PDBj:7vv8
PDBsum7vv8
PubMed35522713
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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