Structure of PDB 7vuj Chain A

Receptor sequence
>7vujA (length=234) Species: 9606 (Homo sapiens) [Search protein sequence]
TEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGADNSGKSTIVK
QMRILGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVDS
SDYNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIED
YFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCY
PHFTCAVDTENARRIFNDCKDIILQMNLREYNLV
3D structure
PDB7vuj Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139.
ChainA
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A D49 N50 S51 G52 K53 S54 T55 N282 K283 D285 A356 D41 N42 S43 G44 K45 S46 T47 N132 K133 D135 A206
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7vuj, PDBe:7vuj, PDBj:7vuj
PDBsum7vuj
PubMed34916631
UniProtP63092|GNAS2_HUMAN Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Gene Name=GNAS)

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