Structure of PDB 7vtp Chain A

Receptor sequence
>7vtpA (length=795) Species: 9606 (Homo sapiens) [Search protein sequence]
DYRKKYRKYVRSRFQCISVSLNKRYTRLRLIKEHRSPIKMELLFDPDDEH
SEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVS
LVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHI
GPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHP
RHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVC
WIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLLCAHLWGLCSLAAD
GIWNQKILFEESDLRNHGLQKADVSAFLRMNLFKFYSFIHMTFQEFFAAM
YYLLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCK
ISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDY
FPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHTSSFCRGLFSVLST
SQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFD
ISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL
TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKL
GLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHP
DCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMF
CEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEP
3D structure
PDB7vtp Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation.
ChainA
Resolution3.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A R167 Y168 T169 G229 G231 K232 T233 I234 F373 Y381 P412 W416 H522 R24 Y25 T26 G64 G66 K67 T68 I69 F208 Y216 P247 W251 H340
BS02 7YN A A227 A228 R351 I411 T439 R578 E629 Y632 A62 A63 R186 I246 T274 R379 E430 Y433
External links
PDB RCSB:7vtp, PDBe:7vtp, PDBj:7vtp
PDBsum7vtp
PubMed35254907
UniProtQ96P20|NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 (Gene Name=NLRP3)

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